Modifiable factors associated with sleep quality should be targeted directly with psychosocial or somatic treatment. Clinicians should remain vigilant for treating subjective sleep complaints independent of residual mood symptoms in those sensitive to poor sleep quality, including individuals with high neuroticism, rapid cycling, and recent stressful life events. Poor sleep quality often persists during euthymia and can be a target for treatment. The best fitting unified multivariable model of poor sleep quality in euthymic participants with BD included rapid cycling ( β = .20, p = .03), neuroticism ( β = .28, p = 2 × 10 −3), and stressful life events ( β = .20, p = .02). Results and discussionĮuthymic participants with BD and HC differed in all domains. A unified model determined independent predictors of sleep quality. Multivariable linear regression models were constructed to investigate the relationship between sleep quality and demographic and clinical variables in BD and HC participants. MethodsĪ retrospective analysis was conducted to assess the association between the Pittsburgh Sleep Quality Index and clinical variables of interest in euthymic patients with DSM-IV BD ( n = 119) and healthy controls (HC n = 136) participating in the Prechter Longitudinal Study of Bipolar Disorder. ![]() ![]() We sought to identify modifiable factors that correlate with poor sleep quality in BD independent of residual mood symptoms. Poor sleep quality is known to precede the onset of mood episodes and to be associated with poor treatment outcomes in bipolar disorder (BD).
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